CuATSM l-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside Medicarpin induces apoptosis and overcome

Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of drugs

3MB-PP1 was not able to significantly inhibit Pti1 and MPK2

Formula: C23H28ClFN4O2

1H3/b20-18+

CuATSM l-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside Medicarpin induces apoptosis and overcomeCuATSM is a highly potent radical trapping antioxidant (RTA) and inhibitor of (phospho)lipid peroxidation, thereby accounting for its (their) ability to inhibit ferroptosis. The metallo protein Cu Zn superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding and aggregation, have been linked to familial amyotrophic